Ultraviolet radiation drives mutations in a subset of mucosal melanomas
نویسندگان
چکیده
Abstract Although identified as the key environmental driver of common cutaneous melanoma, role ultraviolet radiation (UVR)-induced DNA damage in mucosal melanoma is poorly defined. We analyze 10 melanomas conjunctival origin by whole genome sequencing and our data shows a predominance UVR-associated single base substitution signature 7 (SBS7) majority samples. Our with SBS7 dominance have similar genomic patterns to therefore this subset should not be excluded from treatments currently used for melanoma.
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2021
ISSN: ['2041-1723']
DOI: https://doi.org/10.1038/s41467-020-20432-5